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Uma Maheswari B*., Meerabai R.S., 2016. Evaluation of antiinflammatory activity of methanol extract of Ampelocissus araneosa Planch. (Vitaceae) in Wistar albino rats. International Journal of Pharmacy. Photon 107, 512-515
Abstract
The present study was designed to evaluate the anti-inflammatory activity of methanol extract of Ampelocissus araneosa leaf, stem and root at a dose of 200 mg/kg and 400 mg/kg against carrageenan induced rat paw edema and compared to standard drug Indomethacin (10 mg/kg). The results obtained from present study reveals that the methanol leaf extract (400 mg/kg) exhibited high significant activity (p<0.001) within 1hr of administration of the extract, while the other groups showed less significant effect in reducing paw volume
Pharmacy Related Journals
Khare N., Khare P., 2016. Use of Probiotics in Curing Diseases- A Review. International Journal of Pharmacy. Photon 107, 502-506
Abstract
Probiotics is a treatment to control diarrhea in infants and children. Probiotics contain useful such as Lactobacillus and Bifido bacterium spp. in yogurts. These two bacteria play an important role controlling diarrhea. Probiotics also help in maintaining viable microbes mainly during gastro intestinal problems, liver diseases and also in irritable bowel syndrome. So, Probiotics may be defined as use of live microorganism which is beneficial to host. Probiotics also contains sometime strains of yeast for eg. Saccharomyces boulardii which has resulted in effective probiotic. Milk products mainly in fermented form are effective in curing diseases. It also helps in food allergies, and also helpful in curing colonic cancer.
International Journal of Pharmacy and Pharmaceutical Sciences
Citation: Panda N., A.V Reddy., G.V.S Reddy., M.S Ansari., 2015. Biphasic release of Zolmitriptan through design of gastroretentive bilayer floating matrix tablets. International Journal of Pharmacy. Photon 106, 489-501
Abstract The objectives of the present study was to develop a bilayer floating sustained release matrix tablet of Zolmitriptan with biphasic release that increase the residence time in gastric fluid and improves its bioavailability. Floating bilayer tablets having one immediate release layer and another sustained release layer were prepared using direct compression technique. Among all the IR layer formulations, ZIRF10 showed highest f2 value (57.84) and lowest f1 value (10.72) was considered as best formulation. Dry powder blends of all the formulations were evaluated for precompression parameters like angle of repose, Carr’s index and Hausner’s ratio and the results comply with pharmacopeia specification. The formulated tablet were characterized by weight variation, friability, hardness, swelling studies, in vitro release studies, in vitro release kinetic and FTIR and DSC analysis. DSC and FTIR analysis ensured compatibility between the drug and polymers used for formulations. The floating lag time, floating duration and swelling index of ZBFTF10 (optimized formulation) found as 21 second, 13 hour and 101.29 respectively. Out of all the formulation developed, formulation ZBFTF10containing 23% of HPMC K100M and 10% of ethyl cellulose showed optimum in vitro drug release upto 99% at the end of 12 h. The kinetic of in vitro drug release profile of ZBFTF10followed Pappas kinetic model (R2=0.995) having drug release mechanism as anomalous diffusion coupled with erosion (n=0.706). Accelerated stability studies of optimized formulation (ZBFTF10) showed a little change in physicochemical properties as well as drug release profiles at the end of 90 days indicating the stability of formulations. The results of the current study clearly indicated a promising potential of the Zolmitriptan bilayer floating system as an alternative to the conventional dosage form as it released an initial loading dose that can be useful for acute migraine followed by maintenance dose as sustained release manner for better therapeutic benefits. However, further clinical studies are needed to assess the utility of this system for patients suffering from migraine.
International Journal of Pharmacy
Citation: Thakur H.A., Bhamare M.R., Basarkar U.G., 2015. Phytochemical and Antimicrobial activity of Sphaeranthus indicus Linn. International Journal of Pharmacy. Photon 106, 482-488.
Abstract
Sphaeranthus indicus Linn. (Asteraceae) is a common annual spreading herb found in a rice field throughout in India; five crude extracts were prepared from the whole plant Sphaeranthus indicus using different solvents by Soxhlet method. The extracts were subjected to screening to detect Preliminary phytochemical analysis and potential antimicrobial activity against E. Coli, Staphylococcus aureus, Klebsiella pneumonia, Salmonella typhi and fungal strain Candida albicans as standard by agar well diffusion method. The aim of our present study was to find out the Preliminary photochemical analysis and antimicrobial activity of the different extracts of entire plant including flower heads of Sphaeranthus indicus. The different extracts such as Hexane, Methanol, Ethanol, petroleum ether and aqueous extracts exhibits comparable antimicrobial activity with the control. Presence of alkaloids and carbohydrate present in methanol extract, saponins are only present in distilled water and ethanol extract, phenolic compounds are only present in ethanolic extract while fixed oil and volatile oils are strongly present in all extract except in distilled water extract.
American Journal of Pharmacy and Health Research
Citation: Unnithan A.R., Patil S., Unnikrishnan G., 2015. 3D Structure Prediction of Acetylcholineesterase in Aedes aegypti by Multitemplate Modeling. International Journal of Pharmacy. Photon 106, 476-481.
Abstract
Despite the increased sophistication of annotation tools, enzyme acetylcholineesterase in Aedes aegypti remains in the realm of "hypothetical proteins" with little or no structural annotation associated with it. In the present study a systemic investigation was undertaken to make use of multitemplate modeling for the prediction and validation of exact 3D structure of acetylcholineesterase enzyme in Aedes aegypti. Physicochemical properties were analysed by Protparam, 3D structure prediction was performed by multitemplate modelling method using modeller. The reliability assessment of generated model showed the structure quality is good and thus can be used to guide experimental designs.The structural and functional studies of this protein in Aedes aegypti can confer clues for elucidating the functions of genes and proteins underlying specific processes and that can be used to improve vector control measures.
Journal of Pharmacy And Bioallied Sciences
Formulation and in vivo Evaluation of Buccoadhesive Gels Containing Glimepiride: An Antidiabetic Drug
The aim of the present investigation was development and in-vivo evaluation of buccoadhesive gel of an antidiabetic drug i.e., Glimepiride, and to maintain its bioavailability over an extended period of time and to circumvent the hepatic first pass effect. The buccoadhesive gels were prepared using carbopol, hydroxy propyl methyl cellulose, methyl cellulose and sodium carboxy methyl cellulose in different ratios. On the basis of in-vitro studies the formulations GCPH2 and GF16 were selected for in-vivo and stability studies. A maximum hypoglycaemic response was observed at 10 hr and thereafter remained stable up to 24 hr. The formulation GF16 was found stable after stability studies.
Pharmacy
Citation: Abate B., Abera M., 2015. Technology Transfer in Pharmaceutical Industries, Challenges and Opportunities in Developing Countries. International Journal of Pharmacy. Photon 106, 453-463.
Abstract
This review article discloses the issue of pharmaceutical technology transfer in developing countries that has generated and debated for many years. Given technology centrality to development, and technology acquisition necessity by developing countries for further development and benefit, it is desirable to generate, transfer and diffuse the best available pharmaceutical technology in these countries. Unfortunately, most of the world’s advanced technology is generated privately by transnational corporations, whose principal research and development activity is located in developed countries, creates an asymmetry between technology possession and technological need location.
International Research Journal of Pharmacy
There is a gap between the technology developed and owned by firms in developed countries and that can be obtained and utilized by developing countries. The main objective of this review article is to disclose the working procedure for technology transfer process in pharmaceutical industry in developing countries through taking an invention from its inception in a laboratory to a commercialized drug product and to highlight how technology is transferred, importance of technology transfer, reasons for technology transfer, factors influencing technology transfer: drivers and barriers, steps involved in technology transfer and to identify policy approaches that might overcome those barriers.
Journal of Pharmacy and Pharmacology
Citation: Sati S.C., Kumar P., Joshi S., 2015. The bark extracts of Himalayan gymnosperm Picea smithiana (Wall.): A natural sources of antibacterial and antioxidant agent. International Journal of Pharmacy. Photon 106, 445-452.
Abstract
The bark extract of Kumaun Himalayan gymnosperm Picea smithiana was assessed for its active principles. Flavonoids, terpenoid, tannins, alkaloids, saponin, glycosides, quinines, carbohydrates, protein, starch, resin, volatile oil, anthraquinone and phenol were found in both methanol and ethanol bark extracts. The antibacterial potential of methanol and ethanol extracts of bark was investigated against Agrobacterium tumefaciens, Bacillus subtilis, Escherichia coli, Erwinia chrysanthemi and Xanthomonas phaseoli using disc diffusion method.
Indian Research Journal of Pharmacy and Science The extracts were further evaluated for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Both methanol and ethanol extracts of P. smithiana bark were found effective by showing a mark zone of inhibition (ZOI). Methanol extract showed the highest inhibitory activity against A. tumefaciens (ZOI, 19 mm) while ethanol extract exhibited its highest activity for E. chrysanthemi (ZOI, 12 mm).
National Journal of Physiology, Pharmacy and Pharmacology
The MIC and MBC values were recorded in the range 31.25-250 µg/ml and 62.5-500 µg/ml, respectively. The lowest value of MIC and MBC were recorded against A. tumefaciens in methanol extract (31.25 µg/ml and 62.5 µg/ml respectively). The results of bark extracts were also compared with leaf extracts of P. smithiana for antimicrobial potential.
Journal of Pharmacy Practice
Citation: Taderera T., Chagonda L.S., Gomo E., Shai L.J., 2015. Inhibitory activity of α-glucosidase and α-amylase by Annona stenophylla root extract as mechanism for hypoglycaemic control of DM. International Journal of Pharmacy. Photon 106, 436-444.
Abstract
DM mellitus has become a worldwide disease. Some local TMPs in Zimbabwe are reported to have hypoglycaemic effects on blood glucose and are used as herbal medicines to treat diabetes. A. stenophylla aqueous root extracts were freeze dried and examined for inhibition of α-glucosidase and α-amylase on KAT reagents in the presence of sucrose and maltose substrates using acarbose as positive control. The IC50 values for the plant extract and acarbose for α-glucosidase in the presence of the sucrose were 0.123 ± 0.009 mg/ml and 0.101± 0.0176 mg/ml respectively.
International Journal of Pharmacy and Technology
The IC50 values in the presence of maltose were 0.500 ± 0.128 mg/ml and 0.117 ± 0.0563 mg/ml respectively. The plant extract and acarbose showed IC50 values against amylase of 1.26 ± 0.903 mg/ml and 1.199 ± 0.0651 mg/ml respectively. The plant extract displayed mixed type inhibition kinetics for α-glucosidase with sucrose reducing Vmax value of the enzyme from 0.214 to 0.0608 mmoles. min–1 whilst increasing Km from 0.0124 to 0.0580. The results suggest A. stenophylla possesses hypoglycaemic control in diabetes mellitus through inhibition of α-glucosidase and α-amylase enzymes and its standardisation could transform herbal practice in treating diabetes.
American Journal of Health-System Pharmacy
Murugan K., Krishnan M.V.G., Greeshma G.M., Aswathy J.M., Pradeep D.P., Krishnan R., Manoj G.S., 2016. In vivo assessment of DNA damage and its amelioration by essential oil ofArtemisia japonica Thunb. and A. nilagirica (Clarke) Pamp. using single-cell gel electrophoresis and micronucleus assay. The Journal of Phytochemistry. Photon 117, 365-370
Abstract
This study investigated the in vivo genotoxicity of Artemisia japonica Thunb. and A. nilagirica (Clarke) Pamp. and its potential antigenotoxicity against cyclophosphamide (CP) induced DNA damage. Initially, the essential oil (EO) was analyzed by GC-MS. A. japonica and A.nilagirica (250 and 500 mg/kg b.w.) was administered to Swiss white mice of both sexes for 15 days, and the animals received an injection of saline or CP (0.9% NaCl) 24 h before they were euthanized.
Indian Journal of Pharmacy Practice
Journal of Integrated Pharmacy Research and Practice
The GC-MS analysis revealed the presence of Camphor, 8-Cineole, Borneol, Artemisia ketone and β-Thujone the major compounds in A. nilagirica. Meanwhile A. Japonica contain linalool, Caryophyllene oxide, trans-Linalool oxide, p-cymene and 1, 8 -Cineole. Significant inhibitions were observed in the evaluated parameters, demonstrating the absence of cytotoxic and genotoxic effects of EOs at all tested doses.
International Journal of Clinical Pharmacy
In liver, kidney, cardiac and bone marrow cells, EO reduced the DNA damage induced by CP. Results showed a dose–response action of EO. Furthermore, the various tissues showed a difference in the potential antigenotoxic effects. In conclusion, EO of Artemisia was not genotoxic and inhibited the genotoxicity induced by CP. Further investigations are needed to purify the potential compound from EO and also to analyze the effects over human health.
European Journal of Hospital Pharmacy
Pardeshi B.M., 2015. The Biomineral Analysis of Five Indian Ayurvedic Polyherbal Formulations by Instrumental Neutron Activation Analysis (INAA) and Atomic Absorption Spectroscopy (AAS). The Journal of Phytochemistry. Photon 116, 352-364
Abstract
Minerals and trace minerals are essential to human health for maintaining adequate levels in every tissue, fluid, cell and organ in the body may be the key considerations. Medicinal plants are essential natural resource of new bioactive products for drug development.
International Journal of Pharmacy and Integrated Life Sciences
Present study was investigated to the elemental analysis of polyherbal medicinal formulations by Instrumental Neutron activation Analysis and Atomic Absorption Spectroscopy.
International Journal of Pharmacy and Biological Sciences
Medicinal herbals formulations from India, prescribed for specific treatment purposes were analyzed by Instrumental Neutron Activation Analysis using 252Cf, Californium spontaneous fission neutron source(flux *109 n s-1) and the induced activities were counted by γ-ray spectrometry and Atomic Absorption Spectroscopy techniques (Perkin Elmer 3100 Model) available at University of Pune, India was used for the measurement of major, minor and trace elements from five polyherbal Ayurvedic formulations. 15 elements viz. Al, K, Cl, Na, Mn by Instrumental neutron activation analysis and Cu, Co, Pb Ni, Cr, Ca, Fe, Zn, Hg and Cd by Atomic Absorption Spectroscopy were analyzed from different Ayurvedic herbal formulations. A critical examination of the data shows that the elements Ca, K, Cl, Al and Fe are found to be present at major levels in most of the samples while the other elements are present in minor or trace levels. The elemental concentration in different medicinal formulations is discussed.
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